The most likely reason(s) a metastatic tumor cell might lose its connection to the basal lamina would be: a change in the integrin proteins from the cell's surface. a change in the cadherin proteins on the cell surface. a change in connexins disrupting gap junctions. All of these choices are correct.

Answers

Answer 1

Answer:

A change in the integrin proteins from the cell's surface.

Explanation:

Integrin proteins' principal function is to attach the cell to the basal lamina. Also, they transmit signals from the extracellular matrix to the interior of the cell. A change in the integrin could result in loss of connection between the mutated cell and the basal lamina.

Cadherin proteins connect one cell to another. A change in these proteins will not result in the loss of connection between the metastatic tumor cell and its extracellular matrix. It most likely will affect the communication and adhesion of cells.

A change in connexins will disrupt the communication between cells but not the connection to the lamina basal. Connexins are transmembrane proteins that connect one cell to another with gap junctions that allow the passage of different components from cell to cell.


Related Questions

Classify each of the bones in the chart below as either long, short, flat, or irregular by placing a check mark in the appropriate column. Also use a check mark to indicate whether the bone is a part of the axial or the appendicular skeleton. Use Figure 8.1 as a guide. Axial Appendicular Short Flat Irregular skeleton skeleton Long Sternum Radius Parietal bone (cranial bone) Phalanx (single bone of a digit) Vertebra

Answers

"The classification of each bone according to its type (long, short, flat, irregular) and whether it belongs to the axial or appendicular skeleton:

Bone                          Type                              Axial Skeleton                          Appendicular Skeleton

Sternum                           Flat                                   ✔

Radius                           Long                                                                                         ✔

Parietal bone                   Flat                                   ✔

Phalanx (single bone)   Long                                                                                          ✔

Vertebra                           Irregular                            ✔

Long Bones: The bones that are longer than they are wide are called long bones. These bones are found in the appendicular skeleton of the body. The Radius bone is an example of a long bone.

Short Bones: Short bones are as long as they are wide. They are primarily found in the wrist and ankle. The phalanx bone is an example of a short bone.

Flat Bones: Flat bones are thin and flat. These bones protect vital organs and provide a surface for muscle attachment. The Sternum bone is an example of a flat bone.

Irregular Bones: Irregular bones have irregular shapes. These bones play a vital role in protecting the nervous system and the organs in the thorax. The Vertebra bone is an example of an irregular bone.

Axial Skeleton: The axial skeleton consists of bones that lie along the longitudinal axis of the body. The Vertebra and Parietal bone is a part of the axial skeleton.

Appendicular Skeleton: The appendicular skeleton consists of bones that lie along the appendages of the body. The Radius and Phalanx are a part of the appendicular skeleton.

Bones in the human body serve several important functions:

1. Support: Bones provide structural support to the body, giving it its shape and framework. They form the rigid framework that supports and maintains the body's posture.

2. Protection: Bones act as protective coverings for vital organs. For example, the skull protects the brain, the rib cage protects the heart and lungs, and the vertebrae protect the spinal cord.

3. Movement: Bones, along with joints, muscles, and tendons, enable movement. They act as levers that are moved by muscle contractions, allowing us to walk, run, lift objects, and perform various activities.

4. Blood Cell Production: Bones house bone marrow, where red and white blood cells, as well as platelets, are produced. Red blood cells carry oxygen, white blood cells help fight infections, and platelets are essential for blood clotting.

5. Mineral Storage: Bones store minerals, primarily calcium and phosphorus, which are crucial for maintaining the body's mineral balance. When the body needs these minerals, bones release them into the bloodstream.

6. Energy Storage: Yellow marrow, found in the central cavities of long bones, stores fat as an energy reserve for the body.

7. Body Support and Balance: Bones provide support for soft tissues and muscles, allowing them to function effectively. They also contribute to maintaining balance and stability.

8. Sound Transmission: Bones in the middle ear, such as the ossicles (malleus, incus, and stapes), transmit sound vibrations from the outer ear to the inner ear, facilitating hearing.

These functions collectively make bones essential for the body's structure, movement, protection, and overall physiological well-being.

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Match each statement in the left column with the most likely characteristic in the light column. On June 21st. ✓[Choose] 34 degrees the declination of the Sun is 3 degrees north On March 20/2020 is the longest day of the year in the Southern Hemisphere it is the longest day of the year in the Northern Hemisphere On On January 10th, on the Equator, the Solar Altitude is northernmost latitude where the sun rays strike the Earth's surface perpendicularly... 54 degrees the day and night were 12 hours long anywhere between 0 and 60 degrees latitude in both hemispheres 67 degrees N On March 29th 68 degrees farthest distance from the Pole where the sun rays are tangent to Earth's surface. On July 3rd, the latitude of the tangent rays of the Sun is [Choose] On December 20th [Choose] The Tropic of Cancer (23.5 degrees N) is the [Choose] The Antarctic Polar Circle (66.5 degrees 5) is the [Choose ] On January 30th, the solar altitude in Central [Choose] California (about 38 degrees N), is: On April 22nd, the solar altitude in Seattle (about 48 degrees north) is: [Choose]

Answers

On June 21st: The declination of the Sun is 23.5 degrees north.

On March 20/2020: It is the longest day of the year in the Northern Hemisphere.

On January 10th, on the Equator: The Solar Altitude is 90 degrees.

On March 29th: The day and night are 12 hours long anywhere between 0 and 60 degrees latitude in both hemispheres.

On July 3rd: The latitude of the tangent rays of the Sun is 23.5 degrees north.

On December 20th: The Tropic of Capricorn (23.5 degrees south) is the farthest distance from the Pole where the sun rays are tangent to Earth's surface.

On January 30th, the solar altitude in Central California (about 38 degrees N): [Choose]

On April 22nd, the solar altitude in Seattle (about 48 degrees north): [Choose]

Explanation to the above short given answers are written below,

On June 21st, the declination of the Sun is 23.5 degrees north. This means that the Sun is at its highest point in the sky in the Northern Hemisphere, marking the summer solstice.

On March 20th (or around that date), it is the longest day of the year in the Northern Hemisphere. This is the vernal equinox, when the Sun is directly over the Equator and day and night are approximately equal in length.

On January 10th, on the Equator, the Solar Altitude is 90 degrees. This means that the Sun is directly overhead at noon, resulting in a vertical angle of 90 degrees between the Sun and the observer on the Equator.

On March 29th, the day and night are approximately 12 hours long anywhere between 0 and 60 degrees latitude in both hemispheres. This is around the time of the equinoxes when the length of day and night is equal.

On July 3rd, the latitude of the tangent rays of the Sun is 23.5 degrees north. This corresponds to the Tropic of Cancer, the northernmost latitude where the Sun's rays strike the Earth's surface perpendicularly.

On December 20th, the Tropic of Capricorn (23.5 degrees south) is the farthest distance from the Pole where the sun rays are tangent to Earth's surface. This marks the summer solstice in the Southern Hemisphere.

The solar altitude in Central California on January 30th and the solar altitude in Seattle on April 22nd are not provided, so the answers for these statements are missing.

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The Earth rotates counterclockwise on its axis. Because of this, in which direction does the Moon appear to move across the sky?

A. from north to south

B. from south to north

C. from west to east

D. from east to west

Answers

Answer:

East To West

Explanation:

3) identify and describe three abiotic characteristics of ecosystems. Give an example of how each

characteristic could be affected by a human activity

Answers

Answer:

The abiotic characteristics of an ecosystem that affects man includes: Land surface, rainfall and relative humidity.

Explanation:

In the ecosystem, man occupies the terrestrial habitat which is affected by the abiotic factors listed above.

Abiotic (non- living) factors determine the type of biotic (living) community that is found in an ecosystem. These factors include Land surface, rainfall and relative humidity, just to mention a few.

--> LAND SURFACE: This is responsible for the marked variation in the vegetation of a place. For example, a mountain in the tropics may have a rain forest vegetation at it's base and an afroalpine vegetation near its peak. The gradient of the slope affects the growth of organisms. A steep slope encourage fast run - off of water and therefore encourages erosion, which results in shallow and infertile soil. This in turn AFFECT man's farming activities as there would be little to no crop yield.

--> RAINFALL: Water is a very important abiotic factor that affects life. The main source of water to terrestrial habitat is rainfall. When rain falls, a greater percentage of it sinks into the soil while the rest run- off into water bodies. Water is absorbed by root hairs into the plant and used for photosynthesis to produce food. The absence of rainfall in the environment of man could lead to drought which AFFECTS man negatively.

--> RELATIVE HUMIDITY: This is a measure of the amount of moisture in the atmosphere. It's usually high in hot wet regions. It affects the rate at which water evaporates from the body surfaces of organisms. Low relative humidity cause more water (sweat) to evaporate from body surfaces giving the human body a cooling effect. But in high relative humidity, the sweat cannot evaporate leaving the body feeling hot and sticky. This AFFECTS man as the body tries to cool off in a harder way by increasing rate of respiration and depth of blood circulation.

cystic fibrosis is a genetic disease that leads to the production of excessive thick mucus in the respiratory tract, leading to frequent and serious respiratory infections. the defect is due to the production of a faulty membrane protein for the transport of the chloride ion. the protein is still in the membrane; it just doesn't function normally. what type of membrane protein is being affected in this case?

Answers

The type of membrane protein that is affected in cystic fibrosis is a chloride ion channel.

What is Cystic fibrosis?

Cystic fibrosis is an inherited condition in which the mucus in the body becomes thick and sticky. It can cause breathing difficulties and frequent infections, among other symptoms. Because the mucus is thicker than normal, it can obstruct the ducts of the pancreas, preventing digestive enzymes from reaching the small intestine.Cystic fibrosis is an autosomal recessive genetic disorder.

This means that in order to inherit the disease, a person must inherit two copies of the mutated gene, one from each parent.

What is the cause of cystic fibrosis?

Cystic fibrosis is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene provides instructions for making a protein called the cystic fibrosis transmembrane conductance regulator. This protein functions as a chloride ion channel, which helps regulate the flow of salt and fluids in and out of cells.

However, in people with cystic fibrosis, the CFTR protein is either missing or not functioning properly due to a genetic mutation. As a result, the salt and water balance is disrupted, leading to the production of thick, sticky mucus that clogs the airways, digestive tract, and other ducts in the body.

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Witch statement about human activity and the environment is NOT true?

Answers

No body can help u cuz where is the picture
are there answer choices?

which of the following would not be a teratogen? question 18 options: cigarettes lead rubella (german measles) steak

Answers

The following would not be a teratogen among cigarettes, lead, rubella (german measles), and steak is steak. Teratogens are substances that interfere with prenatal development and can lead to birth defects. Cigarettes, lead, and rubella are known teratogens that can cause significant harm to a developing fetus. However, steak is not a teratogen.

Cigarettes are a teratogen because they contain harmful chemicals that can cross the placenta and interfere with fetal development. These chemicals can increase the risk of low birth weight, premature birth, and birth defects such as cleft palate and heart defects.

Lead is also a teratogen because exposure to high levels of lead during pregnancy can lead to developmental delays, learning disabilities, and other cognitive impairments in children. Lead can be found in contaminated water, soil, and household items such as paint and dust.

Rubella, or German measles, is another teratogen that can cause severe birth defects if a woman becomes infected during pregnancy. Rubella can cause deafness, blindness, heart defects, and intellectual disability in a developing fetus.

Steak, on the other hand, is not a teratogen. While some types of food, such as undercooked meat and raw eggs, can be harmful during pregnancy due to the risk of foodborne illness, properly cooked steak is not a teratogen and does not pose a risk to fetal development.

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 HURRY I HAVE A TIME LIMIT!

Humans, cats, whales, and bats all have similar arm bones. What piece of evidence for common ancestry does this describe?

-homology
-embryology
-fossil record
-amino acids sequences

Answers

Answer: that they all have the bones used to make their movements so they can live and survive on there own.

Explanation:

What allele pairs will result from this combination of alleles MmQq? ( use the 13,14,23,24 strategy).
A). All of these are correct
B). MQ, Mq, mQ, mq
C). Mq, mQ, mq, Mq
D). MM, mm, QQ, qq

Answers

The answer is B). MQ, mQ, Mq, mq

What do tornadoes and hurricanes have in common

Answers

☁️ Answer ☁️

"Tornadoes and hurricanes appear to be similar in their general structure. Both are characterized by extremely strong horizontal winds swirling around the center, strong upward motion dominating the circulation with some downward motion in the center. "

1. Death

2. strong horizontal winds swirling around the center

3strong upward motion dominating the circulation with some downward motion in the center.

Hope it helps.

Have a nice day noona/hyung.

Explain the difference between DNA, chromosomes, genes, and the protein that is created.

I NEED THIS QUICKLY PLS!!!

Answers

DNA contains the instructions, genes, to make proteins that tell what genetic traits the person will have. The DNA along with the proteins make up the chromosomes. The chromosomes are then passed on to the offspring, and with the DNA inside the chromosomes and translation of the genes, its traits are decided. Genes are made up of strains of proteins called amino acids

Explanation:

DNA is a long molecule that contains our unique genetic code.DNA is composed of two strands that wrap around each other to form a double helix shape.

Genes are sections of DNA that contain the set of instructions to produce one specific molecule in your body, usually a protein. These proteins control how our body grows and works; they are also responsible for many of our characteristics, such as our eye colour, blood type or height.

Chromosomes are bundles of tightly coiled DNA located within the nucleus of almost every cell in our body. Humans have 46 chromosomes . We inherit one set of 23 chromosomes from our mother and one set of 23 chromosomes from our father. So we have two sets of 23 chromosomes or 23 pairs.

state two factors on which the gravitational force between two objects depends.​

Answers

Answer:

Gravitational Force depends on two factors:

1. Product of mass of two object

2. Square of distance between their centers

Mathematically,

  F = G *(m1* m2)/d²

Explnation:

what might a zoologist notice about birds caged indoors if she were looking for clues that they follow a biological rhythm in natural settings?

Answers

A zoologist notice about birds caged indoors if she were looking for clues that they follow a biological rhythm in natural settings she would observe the birds' behavior closely to detect if they follow a circadian rhythm which is a biological process that occurs within a 24-hour cycle.

The zoologist might notice that the caged birds appear to be restless or sleepless, suggesting that they are uncomfortable or out of sync with their natural rhythms. This is because birds are diurnal animals and require sunlight for proper bodily functions. The zoologist might also observe that the caged birds become increasingly agitated or active during certain times of the day.  This would suggest that the birds are naturally active during those periods in the wild and have maintained this behavior in captivity, indicating a biological rhythm.

Furthermore, the zoologist may notice changes in the bird's behavior in response to changes in lighting, as light is a key regulator of biological rhythms. Birds require a certain amount of light exposure during the day to function properly, and the absence of natural light could disrupt their natural rhythms and cause adverse effects. In conclusion, if a zoologist were looking for clues that birds follow a biological rhythm in natural settings, she might observe changes in the birds' behavior in response to light, as well as changes in activity levels at certain times of the day.

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I
rupe de estudiante utiliza un aparate para estudia
reaction quimica entre pedande cascara de bo
acetico, me muestra la siguiente ilustracion
ar la transferencia de energia durante la
de camara de hormierhonate de calcio vare
Experimento con vinagre y cáscara de huevo
Burbujas
Burbujas
Burbujas
de
Tubo
de
vidrio
Tubo
de
vidrio
vidno
Cáscara de
huevo
Vinagre
Cáscara de
huevo
Vinagre
3
Cáscara de
huevo
Vinagre
5%
Durante el experimento, utilizan la misma masa de cascara de huevo, pere varian la
concentración del vinagre.
A. Explica por yue la transferencia de energia no es la misma entre las tres pruebas del
experimente
B. Describe como se podria modificar el aparato para que pueda medir con MAYOR
EXACTITUD la transferencia de energia en cada reacción.
Recuerda contestar todas las partes de la pregunta en el espacio previsto​

Answers

A. La transferencia de energía no es la misma entre las tres pruebas del experimento debido a la variación en la concentración de vinagre.

La concentración del vinagre influye en la velocidad y la eficacia de la reacción química. El vinagre es una solución diluida de ácido acético en agua, y el ácido actúa para disolver la capa externa de carbonato de calcio que compone la cáscara del huevo. Cuanto mayor sea la concentración de ácido acético en el vinagre, más rápida será la reacción y mayor será la transferencia de energía. Por lo tanto, se puede observar que la prueba que utilizó la concentración de vinagre al 10% tuvo una transferencia de energía mucho más alta que las otras dos pruebas.B.

El aparato se puede modificar para medir con mayor exactitud la transferencia de energía en cada reacción. Esto se puede hacer utilizando un calorímetro, que es un dispositivo que se utiliza para medir el calor de las reacciones químicas o los cambios físicos. El calorímetro consta de un recipiente aislado que contiene una muestra y se coloca en un baño de agua. Se mide la temperatura del agua antes y después de la reacción, y la diferencia en la temperatura se utiliza para calcular la cantidad de calor absorbido o liberado por la muestra.

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Of the three major types of handwriting characteristics line form includes, smoothness of the lines,
pen pressure, and slant
True or False?

Answers

answer: true

explanation:

4. The diagram below represents one possible immune response that can occur in the human body.
**The structures that are part of the immune system are represented by
A, only
A and C, only
B and C, only
A, B, and C

5. Explain your answer to the previous question

Answers

Answer:

A and C only

Explanation:

I'm sorry I don't know how to explain it but trust me its A and C only.

Describe how Mendel performed his pea plant experiments.

Answers

Answer:

Every offspring does not look alike they change with the generations

Explanation:

Light traveling through the air moves in a straight line. An object viewed through water looks different because light rays that travel through water are . . .
A.bent
B.reflected
C.bounced
B.absorbed

Answers

I think The correct answer is c
the answers B , reflected

How might change in one population affect other populations?

Answers

The food chain will mess up.

What can adults do to shrink fat cells?

Answers

Answer: To shrink fat cells, you need to eat fewer calories than your body needs.

CREDIT: healthyeating

Answer:

eat healthily and exercise properly

Explanation:

Innate defenses include mechanical and chemical barriers, whereas adaptive defenses counter specific disease-causing agents.

True or False

Answers

True have a good one :)




bynummeeks24

10/08/2020

BiologyHigh School

answered

Which of the following best describes how a channel protein moves materials across the membrane? A)They provide a carrier for specific molecules to bind to and cross the membrane via endocytosis. B)They provide a passage for specific molecules to cross the membrane via passive transport. C) They provide a tunnel for solutes to cross the membrane via active transport. D) They provide energy needed for solutes to cross the membrane via facilitated diffusion.

Answers

The correct option that best describes how a channel protein moves materials across the membrane is B) They provide a passage for specific molecules to cross the membrane via passive transport.

Channel proteins are integral membrane proteins that form channels or pores in the cell membrane. These channels allow the passive transport of specific molecules or ions across the membrane down their concentration gradient. This process is called facilitated diffusion, where the molecules move from an area of higher concentration to an area of lower concentration without the need for energy input. The channel proteins provide a selective passage for these molecules, enabling their movement across the membrane.

Therefore, the correct answer is B) They provide a passage for specific molecules to cross the membrane via passive transport.

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What is the difference between a) prokaryote and eukaryote; b) autotroph and heterotroph; c) unicellular and multicellular?

Answers

Answer:

Explanation:

a) eukaryotes have membrane bound organelles like nuclei while prokaryotes don't

b) autotrophs = producers that can make their own food while heterotrophs consume producers or other consumers

c) Unicellular organisms are made up of only one cell that carries out all of the functions needed by the organism, while multicellular organisms use many different cells to function

Consider the relationship between UV exposure (e.g. UV exposure...
Consider the relationship between UV exposure (e.g. UV exposure time) and colony formation in trp1-289 yeast plated on SD medium. (1pt) Would you predict there to be a positive or negative relationship between UV exposure and colony formation (i.e. number of colonies) in trp1-289 yeast plated on SD medium. Why? (1pt) If you were to graph this relationship, which variable (i.e. number of trp1-289 colonies on SD medium or UV exposure time) would go on the x-axis and which would go on the y-axis? (1pt) Explain why this relationship might not be linear? (Hint: use the information you generated in Q3&4 above). Include a description of what this relationship might look like?

Answers

The relationship between UV exposure and colony formation is negative.

There is a negative relationship between UV exposure and colony formation in trp1-289 yeast plated on the SD medium. This is because UV exposure can cause DNA damage, which can lead to decreased viability and colony formation in yeast.

The UV exposure time would be placed on the x-axis, representing the independent variable. The number of trp1-289 colonies on the SD medium would be placed on the y-axis, representing the dependent variable.

The relationship between UV exposure and colony formation might not be linear due to several factors. The relationship might exhibit a sigmoidal or exponential decay curve.

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What is one disadvantage of desalination?

The process can ultilize solar energy to lower its cost.
The process uses fuel that is expensive.
The process makes water that is unsafe to drink.
The process is too difficult to carry out in big cities.

Answers

Answer:

B

Explanation:

Desalination remains expensive, as it requires enormous amounts of energy. The correct answer is b) The process uses fuel that is expensive.

What is desalination?

Saline water which is typically sea water, is artificially transformed into fresh water through a process called desalination. Reverse osmosis and distillation are the two most used desalination techniques. There are several approaches. Although each has benefits and drawbacks, they are all useful.

The issue is that it takes a lot of energy to desalinate water. When salt is dissolved in water, it forms strong chemical bonds that are challenging to break. Desalinating water may be rather expensive since both the energy and the technology required are costly.

Desalination turns seawater into freshwater by removing the salt, however, it also has certain unfavorable effects on the ecosystem. Desalination facilities release trash and poisonous chemicals that are bad for the environment and animals. The procedure can also increase the salinity of saltwater, which has an impact on fish.

Therefore, the correct answer is b).

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What are the factors that increase a species success over time.

Answers

Answer:

Explanation:

(1) the potential for a species to increase in number,

(2) the heritable genetic variation of individuals in a species due to mutation and sexual reproduction,

(3) competition for limited resources

(4)  the proliferation of those organisms that are better able to survive and reproduce in the environment

Hope this helped!!!

Beneficial bacteria are found in our digestive tract

A. true
B. False

please help

I will give brainliest and 5 * and 10 points for the best answer

I don't want to see an link if I do you will be reported

Answers

(A), because there are bacteria your body don’t attack because they are helpful.

TRUE/FALSE> littoral zones are more likely to contain vegetation than riparian zones. please select the best answer from the choices provided

Answers

Littoral zones are more likely to contain vegetation than riparian zones. This statement is TRUE.

Littoral zone: This is the region of a body of water close to the shore. The littoral zone is the area of the lake where the rooted plants are able to grow. It is the area of the lake where sunlight penetrates all the way to the sediment and allows aquatic plants to grow. Therefore, the littoral zone is more likely to contain vegetation than riparian zones. Riparian zone: This is the area adjacent to a stream or river. Riparian zones are unique and provide a diverse range of habitats for different species. The vegetation in this zone is very important for the proper functioning of stream and river ecosystems. While it may contain vegetation, the likelihood is lower than that of the littoral zone.

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Given the following sense strand of DNA sequence, transcribe it into mRNA, showing the orientation of the mRNA [i.e. 3' and 5' ends]. Then translate this sequence into protein [indicating amino and carboxy termini, be sure to check for an open reading frame as well.]
5' GGGATCGATGCCCCTTAAAGAGTTTACATATTGCTGGAGGCGTTAACCCCGGA 3´

Answers

The correct mRNA sequence transcribed from the given DNA sequence is: 5' UCCCUAGCUACGGGAUUUUCUCAAUAUGUAAUUGACCUCCGCAAUGGGGCUCC 3' Here option B is the correct answer.

To determine the correct mRNA sequence transcribed from the given DNA sequence, we need to apply the rules of DNA transcription. During transcription, the DNA sequence is used as a template to synthesize an mRNA molecule, with the RNA base uracil (U) substituting for thymine (T) in the DNA.

The given DNA sequence is:

5' GGGATCGATGCCCCTTAAAGAGTTTACATATTGCTGGAGGCGTTAACCCCGGA 3'

To transcribe this DNA sequence into mRNA, we replace each DNA base with its RNA counterpart:

G (Guanine) → C (Cytosine)

C (Cytosine) → G (Guanine)

A (Adenine) → U (Uracil)

T (Thymine) → A (Adenine)

Applying these conversions, we get the mRNA sequence:

5' CCCUAGCUACGGGAUUUUCUCAAUAUGUAAUUGACCUCCGCAAUGGGGCUCC 3'

Therefore, option b) 5' UCCCUAGCUACGGGAUUUUCUCAAUAUGUAAUUGACCUCCGCAAUGGGGCUCC 3' represents the correct mRNA sequence transcribed from the given DNA sequence.

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Complete question:

Which of the following represents the correct mRNA sequence transcribed from the given DNA sequence?

a) 5' GGGATCGATGCCCCTTAAAGAGTTTACATATTGCTGGAGGCGTTAACCCCGGA 3'

b) 5' UCCCUAGCUACGGGAUUUUCUCAAUAUGUAAUUGACCUCCGCAAUGGGGCUCC 3'

c) 5' CCCUAGCUACGGGAUUUUCUCAAUAUGUAAUUGACCUCCGCAAUGGGGCUCC 3'

d) 5' GGGATCGATGCCCCTTAAAGAGUUUACAUUAUUGCUGGAGGCGUUAACCCCGGA 3'

You aim to chemically synthesize four peptides with the following one-letter amino acid sequences: TIGER, PANTHER, CHEETAH, and CAT. A.Which one of these peptides will have the lowest pl? Give a reason for your answer. You are not required to calculate the pls of the peptides to answer this question. A qualitative knowledge of the ionization properties of amino acids discussed in class is sufficient to answer this question (4 points). B. Based on what we learned in the lectures, draw the titration curve for the GEAR peptide in the pH range 0-14. Make sure to label the two axes, and the pk1, pk2, and pkr values on the curve. If there are multiple R groups that titrate, indicate the pkrs as pKR1, PKR2 etc. You are not required to write out the chemical structures of the various titration intermediates (8 points). C. While entering the sequence in into the automated peptide synthesizer you mistakenly type in CHETAH instead of CHEETAH. So, you synthesize a peptide with the wrong sequence. However, you realize something is wrong as soon as you do a pH titration of the peptide. What is one difference be- tween the pH titration curves for the peptides CHEETAH and CHETAH? You can either answer in words alone or with help of pH titration curves (4 points).

Answers

The peptide CAT is expected to have the lowest pI due to its composition of basic amino acids.

The pI of a peptide is influenced by the ionizable amino acid residues it contains. CAT, among the given peptides, is composed mainly of basic amino acids such as arginine and lysine. These basic amino acids have higher pKa values for their side chains, resulting in a net positive charge at lower pH values.

The pI is the pH at which a peptide carries no net electrical charge, and in the case of CAT, it is likely to be lower due to the prevalence of basic amino acids. Peptides with acidic or neutral amino acids would have higher pI values, as their side chains have lower pKa values and tend to be negatively charged at lower pH values.

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You aim to chemically synthesize four peptides with the following one-letter amino acid sequences: TIGER, PANTHER, CHEETAH, and CAT. A.Which one of these peptides will have the lowest pl? Give a reason for your answer. You are not required to calculate the pls of the peptides to answer this question.

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