Mutation of the muscle-specific intermediate filament desmin leads to the rare disease desmin-related myopathy. This disorder starts with weakness of the lower limbs when patients are in their 20s or 30s. As symptoms worsen, weakness in respiratory and cardiac muscles occurs, which can lead to serious problems including sudden cardiac arrest.
Which of the following mutations would disrupt desmin intermediate filament structure or function and could explain the symptoms of desmin-related myopathy? Choose all of the possible mutations.

Answers

Answer 1

mutations would disrupt desmin intermediate filament structure or function. the symptoms of desmin-related myopathy are:

(A) Mutation such that formation of dimers is blocked.

(B) Alteration in the twist or coiling of the dimers, blocking formation of staggered tetramers.

(C) Disruption of the polarity of the final desmin strands.

Desmin is an intermediate muscle-specific filament protein. Intermediate filament protein of great importance in smooth, skeletal and cardiac muscle.

Desmin-associated myopathy is a disease in which desmin is mutated. The effect of this mutation on desmin causes muscle weakness in both the lower and upper extremities, respiratory failure (breathing problems), weakness of the heart and skeletal muscles, and irregular heartbeats that can lead to heart attacks. There is a possibility.

Mutations that may lead to this desmin-associated myopathy include:

Mutation such that formation of dimers is blocked.Alteration in the twist or coiling of the dimers, blocking formation of staggered tetramers.Disruption of the polarity of the final desmin strands.

your question is incomplete, but most probably the full question was

Mutation of the muscle-specific intermediate filament desmin leads to the rare disease desmin-related myopathy. This disorder starts with weakness of the lower limbs when patients are in their 20s or 30s. As symptoms worsen, weakness in respiratory and cardiac muscles occurs, which can lead to serious problems including sudden cardiac arrest. Which of the following mutations would disrupt desmin intermediate filament structure or function and could explain the symptoms of desmin-related myopathy? Choose all of the possible mutations.

(A) Mutation such that formation of dimers is blocked.

(B) Alteration in the twist or coiling of the dimers, blocking formation of staggered tetramers.

(C) Disruption of the polarity of the final desmin strands.

(D) Alteration in head groups, so tetramers are unable to link end to end.

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Related Questions

Chemicals used to kill insects and rodents are
solvents.
herbicides.
pesticides.
dioxins.

Answers

Answer:

Explanation:

herbicides.

Which of the following technological advancements allows scientists to study cells?

Answers

The invention of microscopes

Calculate the total amount of fibre there would be in a meal containing 200 g of chicken, 200g of rice and 100g of spinach. Show your working.

Answers

You start by doing the 200g with the 200g which means 200g x 200g then you have to add you total with 100g which is 200g x 200g + 100g

Knowledge of the structure of DNA is important in the study of life because DNA

Answers

Knowledge of the structure of DNA is important in the study of life because DNA is the genetic material that carries the instructions for the development and function of all living organisms. Understanding the structure of DNA and how it works allows scientists to better understand how living things grow and develop, how they evolve and adapt over time, and how they respond to different environments and stimuli.

DNA is a long, double-stranded molecule that is composed of nucleotides, which are the building blocks of life. Each nucleotide is made up of a sugar, a phosphate group, and a nitrogenous base (adenine, guanine, cytosine, or thymine). The sequence of these nitrogenous bases determines the genetic information that is carried by DNA, and this information is used to direct the synthesis of proteins, which are the primary functional molecules in living cells.

By understanding the structure and function of DNA, scientists are able to study how genes are inherited, how they are expressed, and how they can be altered or mutated. This knowledge has led to significant advances in the fields of genetics, molecular biology, and medicine, and it has had a major impact on our understanding of the nature of life and how it works.

glycolosis that starts with glycogen instead of glucose can be considered to have a higher energy yield because

Answers

Glycolysis that starts with glycogen instead of glucose can be considered to have a higher energy yield because, phosphorylase produces a glucose phosphate without spending any ATP to do it.

How does glycogen affect glycolysis?Glycogen degradation in myocytes provides the energy needed for muscle contraction by introducing glucose-6-phosphate for glycolysis reaction. Phosphorylase kinase is an enzyme that activates glycogen phosphorylase, which releases glucose-1-phosphate from glycogen.Glucose phosphate is the initial intermediate of glucose metabolism and is essential for the liver's energy metabolism. It serves as a metabolic connector for glycolysis, the pentose phosphate route, glycogen synthesis, de novo lipogenesis, and the hexosamine pathway.The presence of glycogen as a glucose source in muscle cells allows ATP to be produced for a longer period of time during exercise. During glycolysis, the majority of other carbohydrates enter the cellular respiration pathway.

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Advantages of thermal method 1) The basic process technology is available and reasonably well developed. 2) Can be scaled to handle large volumes of liquid waste. 3) An excellent disposal method for biologically hazardous wastes. 4) Large areas of land are not required. 5) Reduction of leachability of the wastes after it is incinerated, thus making

Answers

Option 3 is the correct answer, An excellent disposal method for biologically hazardous wastes is advantages of thermal method.

Rapid heating and minimal water hazardous wastes component loss are benefits. High initial investment expenditures and potential thermal method problems with heating homogeneity disposal are drawbacks. As a result of less leaching disposal , this approach is suited for foods with high chopped surface surfaces. Thermal waste treatment is the use of heat to treat waste products. The ideal technique of disposing of hazardous wastes is by incineration. Thermal method for waste management seek to minimize waste volume and transform garbage into hazardous wastes compounds.

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HELP MEE I NEED THIS DONE ASAP

Answers

Hypothesis testing is a formal technique for using statistics to test our ideas about the world. It is most commonly used by scientists to test certain predictions derived from a theory called a hypothesis.

There are five main steps in hypothesis testing.

State the research hypothesesCollect data in a manner designed to test the hypothesis.Performs appropriate statistical tests.Determines whether  to reject the null hypothesis.Present the results in the Results  and Discussion section.

What is the role of mitochondria?

The classic role of mitochondria is oxidative phosphorylation, which uses the energy released during the oxidation of the food we eat to generate ATP. ATP, in turn, is used as the primary energy source for most biochemical and physiological processes, including growth, locomotion, and homeostasis.

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If the experimenter is concerned about subject variables impacting the results of a study, a researched might find it best to use a _____

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If the experimenter is concerned about subject variables impacting the results of a study, a researcher might find it useful to use a restriction.

Subject variables are characteristics that can't be manipulated by the researchers conducting experiments. They are not a primary interest of the research but may influence the study result and thus must be accounted. Some examples of subject variables are age, intelligence, marital status, and religious affiliation.

Generally, there are four methods that one can do to decrease the impact of subject variables:

Restriction: restricting samples by only including subjects that fulfill certain criteria.Matching: match each subject with a counterpart.Statistical controlRandomization: assign treatment in study randomly.

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Analyze Methods What might be a major drawback of grouping protists based on how they get food?​

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Simple eukaryotic organisms known as Protists are not classified as either plants, animals, or fungus. Although they are often unicellular, Protists can also be found as a colony of cells.

Why is it difficult to classify protists?Because the kingdom protists includes species with characteristics similar to those of plants, mammals, and fungi, it lacks a clearly defined boundary and establishes a connection with these three other kingdoms. This kingdom is diverse. Therefore, it is challenging for biologists to reach consensus on a protist taxonomy.The absence of other eukaryotes means that protists do not constitute a natural group, or clade, even though it seems likely that they all descended from a common ancestor.Sequence analysis have uncovered novel genetic links among these eukaryotes, disassembling the Kingdom Protista. Furthermore, rather than sharing a recent common ancestor, protists with identical morphological characteristics may have evolved homologous structures in response to similar selective forces.Protist classification is difficult in part because of a phenomena known as convergent evolution.

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which new chromosome(s) would represent an inversion of a chromosome that originally contained the segments ABCDE?ACBDEADCBEABBCDECDEABDCEABCXYZAnswer:ACDEACBDEADCBEABDCE

Answers

The new chromosomes would look like : ACBDE, ADCBE, ABDCE

What are the chromosomal sequences ?

A procedure carried out in the lab to ascertain the complete genetic make-up of a particular organism or cell type is called chromosomal sequencing . This approach can be used to detect changes in specific regions of the genome. These modifications could aid research into how particular diseases, like cancer, develop.

Chromosomes are found in the cell nucleus of all plants, animals, and humans. There are 46 chromosomes in humans, including one pair of sex chromosomes (XX or XY) and 22 pairs of numbered chromosomes (autosomes).

There are four different kinds of DNA nucleotides that are naturally occurring nitrogenous bases: adenine (A), thymine (T), guanine (G), and cytosine (C).

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(mitosis and the cell cycle fill in the blanks)
the cells at each phase of the cell cycle are shown as being the same size. In reality, the daughter cells are bigger than ___ smaller than ___ the same size as ___ the cells at the end of the G1, S, and G2 phases.

Answers

The cells at each phase of the cell cycle are shown as being the same size. In reality, the daughter cells are bigger than the parent cells, smaller than the parent cells, the same size as the parent cells at the end of the G1, S, and G2 phase.

What are mitosis and the cell cycle?

Mitosis is defined as the process of cell division that occurs in cells in which the cell grows, divides, and produces daughter cells that have the same number of chromosomes as the parent cells.

The cell cycle refers to the cycle in which the cell passes through four stages to produce two daughter cells from a parent cell.

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The largest form of pathogen is
bacteria.
fungi.
parasitic worms.
protozoa.

Answers

Answer:

Hi!

The answer would be C) parasitic worms.

I hope this helped you! :)

Which statement best describes why computer models are useful in science?

a.They can store and process data to make accurate weather predictions.
b.They are used to create more complex representations of large systems.
c.They cannot be revised after they are developed, tested, and shared with others.
d.They can be used to accurately make predictions without scientific evidence.

The answer is: a.They can store and process data to make accurate weather predictions.

Answers

Answer:

A

Explanation:

They can store and process data to make accurate weather predictions.

Which of the following is the process of detecting environmental stimuli and converting them into signals that can be detected by the nervous system?
(A) perception
(B) sensation
(C) top down processing
(D) difference threshold
(E) false alarm

Answers

Process of detecting environmental stimuli and then converting them into signals that can be detected by  nervous system is called: B) sensation.

What is meant by sensation?

Sensation is the process by which we receive information from the environment and our senses respond to a limited range of environmental stimuli. We cannot hear sound of frequencies above 20,000 Hz but dogs can hear them.

Stimuli means an event that causes a functional reaction in a tissue or organ and is the detectable change in the structure of an organism.

Reception is the first step in sensation. Reception is the activation of sensory receptors by stimuli such as mechanical stimuli, chemicals, or temperature.

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Select all that are required for the definition of a transcription factor
1.Binds to a specific sequence
2.DNA Alters the affinity of the polII
3.Alters the topology of the DNA
4.Is located a long distance from the promoter

Answers

A transcription factor - Binds to a specific sequence and alters the topology of the DNA.

The correct option is 1 and 3.

Transcription factors are proteins that bind to nearby DNA to help turn certain genes "on" or "off." Transcription factors that function as activators promote the transcription of a gene. Reducers make transcription easier.

It is located near the promoter and alters the topology of the DNA.

An enhancer or silencer is a collection of transcription factor binding sites that may turn a gene on or off in a particular region of the body.

Cells may "decide" whether to express a gene by using transcription factors to execute logic operations and incorporate several sources of information.

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Help please will mark as brainliest!!

Answers

There is a mojor relationship between carbon and human activities represented in the model.

What is human activities?

Human activities are to the various actions for the  recreation, living, or necessity done by the person or the people For instance it includes leisure the  entertainment, manufacturing, recreation, of the  war, and exercise.

Humans are moving more Carbon into the atmosphere with things like fossil fuels. We are also cutting down trees and other plants that actually take carbon away from our atmosphere through photosynthesis and adding oxygen. This is causing the carbon to get stuck in the atmosphere and contaminating our air.

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Hormones are the chemical communicators of which biological system?

Answers

Answer:

endocrine system

Explanation:

hormones are produced by the endocrine glands of the endocrine system as a way of sending messages

Please briefly describe yourself in 3-4 sentences.

Answers

Answer:

To give a correct answer, you'd have to describe yourself. But if you're asking me this question, then I'd say:

I am a outgoing, extroverted funny person. I am also considered artistic and smart. I often push boundaries of others and don't realize, yet I'm working on that.

If dna is damaged or incompletely replicated in s phase, the inhibition of which of these molecules prevents the cell from entering m phase?.

Answers

cd25 is a molecule. Inhibition of these molecules prevents cells from entering m phase

Mitosis or M phase includes nuclear division and cytokinesis during which her two identical daughter cells are produced. Mitosis includes prophase, prometaphase, metaphase, anaphase, and telophase. Finally, cytokinesis leads to cell division. Cell division occurs in the M phase, which consists of nuclear division (mitosis) followed by cytokinesis (cytokinesis). DNA is replicated in the previous S phase. Two copies of each duplicated chromosome (called sister chromatids) remain glued together by cohesin. Mitosis is usually divided into four stages: prophase, metaphase, anaphase, and telophase. This is illustrated in Figures 14.23 and 14.24 for animal cells.

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What happens to daphnia heart rate when the temperature rises ?

Answers

Answer:

It'll receive less oxygen

Explanation:

Less oxygen would be present in the warmer water, which could be one explanation for Daphnia's heart rate rising with temperature. Because there may not be enough oxygen in the blood, the heart would have to work harder to pump blood throughout the body.

Read the statement.

Earth’s climate is the result of many different variables interacting over time. Scientists study these variables to develop accurate models that can be used to make predictions about how Earth's climate will change.

Which of the following variables are involved with producing Earth’s climate?

Choose all that apply:

Species extinctions.

Human activities.

Greenhouse gases.

Solar energy and ice interactions.

Answers

Human activities is the major variable involved in producing Earth's climate.

What human activities affect the climate?

The loss of biodiversity and the progression of climate change are two issues that are intertwined and contribute to one another. The composition, function, and structure of many ecosystems and species have been severely affected as a result of rising temperatures and other climatic impacts, with some of these changes being irreversible.

The physical environment is affected by humans in a variety of ways, including pollution, deforestation, excessive population growth, and theb. These kind of shifts have been found to be the root cause of climate change, soil erosion, poor air quality, and water that is undrinkable.

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HELP IM ON LIMITED TIME!

Given the following phylogenetic tree from animals that lived during the Cambrian Era of prehistory, which two classes of arthropods are the most closely related?

Select one:

Insecta and crustacea

Myriapoda and crustacea

Arachnida and insecta

Trilobita and arachnida

Answers

Trilobita and arachnida

What is the purpose of our stress response system?
Will mark brainiest please hurry a unit test please hurry

Answers

Answer: To keep you safe in emergencies

Explanation:

The stress response, or “fight or flight” response is the emergency reaction system of the body. It is there to keep you safe in emergencies. The stress response includes physical and thoughtful responses to your perception of various situations. When the stress response is turned on, your body may release substances like adrenaline and cortisol. Your organs are programmed to respond in certain ways to situations that are viewed as challenging or threatening.

adrenal glands produce a variety of hormones influencing sodium retention, glucose metabolism, estrogen production, and sympathetic nervous activity. responses

Answers

True adrenal glands produce a variety of hormones influencing sodium retention, glucose metabolism, estrogen production, and sympathetic nervous activity, responses

What hormones are produced by adrenal glands ?

On top of your kidneys are your adrenal glands, which are endocrine glands. Cortisol, aldosterone, and adrenaline are just a few of the crucial hormones they produce. Your body's response to stress, blood pressure, metabolism, and other bodily processes are all controlled by the adrenal hormones.

Small, triangular-shaped glands called adrenal glands, or suprarenal glands, are situated atop each kidney. Your immune system, blood pressure, response to stress, and other vital processes are all regulated by the hormones that your adrenal glands produce.

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What is the difference between mitochondrial and cell DNA-based fingerprinting analysis?

*Question on my Gel Electrophoresis Lab

Answers

Nuclear DNA is bulkier than mitochondrial DNA. The main difference between mitochondrial DNA and nuclear DNA is that mitochondrial DNA contains the genetic information required for mitochondria, whereas nuclear DNA contains the genetic information required by the entire cell.

what is mitochondrial ?

Mitochondria are frequently referred to as the "powerhouses" of the cell. They help transform the energy we get from food into energy the cell can use.

what is cell DNA?

DNA, commonly referred to as deoxyribonucleic acid, is the genetic material carried by humans and nearly all other organisms. A person's cells almost all have the same DNA.

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the level of an antimicrobial agent which will eliminate the pathogen if the level is maintained over a period of time ___ .

Answers

The level of an antimicrobial agent which will eliminate the pathogen if the level is maintained over a period of time _therapeutic dosage level__ .

What is therapeutic dosage level ?

A therapeutic dosage is a radiation dose administered to a patient or human research subject from a sealed source that contains radioactive material for palliative or curative treatment.

The relative safety of a medicine is quantified by the therapeutic index (TI; also known as the therapeutic ratio).

In general, the dosage of a medication or other therapeutic agent with a narrow therapeutic range—i.e., minimal difference between toxic and therapeutic doses—can be changed in accordance with measurements of the actual blood levels attained in the patient. Therapeutic drug monitoring (TDM) methods can help with this. Due to TDM's limited therapeutic range, it is advised to use it in conjunction with lithium to treat psychiatric disorders.

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The biological species concept works well with all of the following, except
A. bacteria B. insects C. mammals D. flowering plants

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The biological species concept works well with all except bacteria.

What is the biological speciation concept?A species taxon is a collection of creatures that may effectively interbreed and give birth to viable offspring, according to the Biological Species Concept. That idea holds that both interbreeding within a species and reproductive barriers between creatures of various species help to protect the integrity of a species.The process of speciation results in the emergence of new species. An ancestor species that can no longer interbreed separates into two or more descendant species that are genetically distinct from one another during speciation.The biological species concept (BSC) was created to help people comprehend biological variety, notably the widely acknowledged finding that sexually reproducing organisms are more likely to be found in genetic and phenotypic clusters than in a continuum of forms.

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The images show the events that occur in your body after you eat a sugary snack. Put the events in the correct sequence.
1. Blood glucose levels become high
2. pancreas releases insulin
3. Insulin binds to receptors on target cells
4. Cells take in glucose
5. Blood glucose returns to normal

Answers

When blood sugar levels are high, the pancreas releases insulin, which attaches to receptor on target cells and causes the cells to take up glucose. Once the blood sugar levels are normal again.

What causes and what causes blood pressure?

Blood pressure is influenced by both how quickly the heart beats and how difficult it is for blood to move through arteries. As the heart is pumping more plasma and as the capillaries narrow, blood pressure rises.

What causes blood pressure to rise the most?

What causes blood pressure to increase? High blood pressure typically develops gradually. Unhealthy lifestyle choices, such as failing to get enough regular exercise, can be a factor. Diabetes and obesity are two conditions that could raise the risk of getting high blood pressure.

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What is the name of the structure in the inner ear which serves to maintain a sense of equilibrium and orientation in space?.

Answers

The vestibular system in the inner ear serves to maintain a sense of equilibrium and orientation in space.

The vestibular system is the sensory system present inside the ear. It detects the position and movement of head. Therefore it provides the sense of balance and body position. The vestibular system is comprised of utricle, saccule, and three semicircular canals.

Ear is the organ of hearing and balance of the body. The ear is divided into three sections: outer, middle and inner. The outer ear is called pinna and is made up of cartilage and skin. The middle ear has the structure related to hearing and the inner ear provided the balance to the body.

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Adaptations are characteristics
that increase an organism's
chance of survival in their
environment. Which is TRUE
about adaptations?
Only herbivores have adaptations.
They must be inherited. This is answer

Answers

Answer: They must be inherited.

Explanation:

All types of animals can have adaptations. Herbivores, carnivores, omnivores, alongside bacteria and viruses

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Definition query Which policy was developed by the industrialized nations as the need for more food and raw materials increased?