Glycogen synthetase kinase 3 beta is a protein kinase that has been implicated in many types of cancer. Depending on the cell type, the gene for glycogen synthetase kinase 3 beta (GSK38) can act ether as an oncogene or as a tumor suppressor. Which of the following best predicts how GSK 98 mutations can lead to the development of cancer? A Cells with inactive GSK 38 fail to trigger apoptosis. B Cells with inactive GSK 38 fail to proceed past the G2/M checkpoint. с Cells with overactive GSK 98 are more likely to repair DNA damage. Cells with overactive GSK 38 have longer cell cycles.​

Answers

Answer 1

Answer:

A Cells with inactive GSK 38 fail to trigger apoptosis

Explanation:

Apoptosis is defined as the process of programmed death cell. Tumor cells are capable of evading apoptosis, thereby leading to uncontrolled cell proliferation. Glycogen synthase kinase 3 (GSK-3) is a protein kinase that phosphorylates serine and threonine amino acid residues on different substrates, thus activating different signaling pathways and having different biological functions. The GSK-3-mediated phosphorylation on different substrates may lead to the activation or inactivation of apoptosis depending on the cell type. Thus, GSK-3 has a dual activity and functions as a tumor suppressor and oncoprotein.


Related Questions

PLEASE HELP!!!!! PLEASE HELP!!!

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Answer:

its "A" water flowing over a tall cliff

Explanation:

the answer to the question is "A"

Help plzzzzzzzzzzzzzzzzz

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Answer:

A) It helps to separate the chromosomes

Explanation:

please help its due in a hour!!!!!

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Answer:

1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).

2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).

Explanation:

In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.

Normal hemoglobin protein in a RBC

DNA                 CTG ACT CCT GAG GAG AAG TCT

Amino acids     Leu  Thr   Pro   Glu   Glu   Lys   Ser

Sickle cell hemoglobin protein in a RBC

DNA                 CTG ACT CCT GTG GAG AAG TCT

Amino acids     Leu  Thr   Pro   Val   Glu   Lys   Ser

When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease.

Madison's group lab is given a dish that contains sand, shells and water. How should they classify the substance they have been given?

A: The solution is a homogenous mixture because it has the same uniform appearance and composition throughout
B: The solution is a heterozygous mixture because it does not have the same uniform appearance or composition.
C: The substance is a compound because it contains several elements.
D: The substance is a pure substance because it's made up of various compounds.

Answers

The answer is D I took the test

A half-life is the time required for one half of the atoms of a radioactive substance to decay. Do these special type of atoms continue to decay until they become stable atoms and they do not give off energy anymore?

Answers

Answer:

Half-life, in radioactivity, the interval of time required for one-half of the atomic nuclei of a radioactive sample to decay (change spontaneously into other nuclear species by emitting particles and energy), or, equivalently, the time interval required for the number of disintegrations per second of a radioactive

Explanation:

Make a food web for the rainforest
(No pictures needs to be written)

Answers

Answer:

Producers are bamboo trees, coconut trees, banana tree, shrubs , bromeliads e t.c.

The primary consumers are monkey, grasshopper, bats, macaws, butterflies, sloths.

Secondary consumers are iguanas, vampire bats, frogs.

Tertiary consumers are Jaguar and python.

Decomposers are insects, microorganisms.

Explanation:

Food webs refers to association that comprises of interconnections of several food chains or what organisms feed on or live on in an ecological community. Food web comprises of producers, primary consumer, secondary consumer , tertiary consumer and decomposers.

If you could see the new moon, at what time of day (roughly) would it rise?
Astronom

Answers

Answer:

Rises at sunrise, transits meridian at noon, sets at sunset.

Explanation:

I think this is the closest answer :)

Which of the following are ways that the respiratory system works with the immune
system to keep humans from getting sick? (Choose all that apply
1.) Coughing involves a quick contraction of the diaphragm muscle, forcing air
through the respiratory pathway, and dislodging mucus or other harmful
particles
2.) Alveoli transfer bacteria and viruses to the bloodstream to be disposed of.
3.) Cilia function like a filter, trapping dust and pollen in the nose,
4.) Mucus traps bacteria and viruses to be removed or swallowed.

Answers

Answer:

1.) Coughing involves a quick contraction of the diaphragm muscle, forcing air

through the respiratory pathway, and dislodging mucus or other harmful

particles

3.) Cilia function like a filter, trapping dust and pollen in the nose,

4.) Mucus traps bacteria and viruses to be removed or swallowed.

Explanation:

Coughing involves a quick contraction of the diaphragm muscle, forcing air out while the cilia act like a filter, trapping dust and pollen in the nose. Mucus traps bacteria and viruses to remove or swallow. So, the correct options are A, C and D.

What is Respiratory system?

The respiratory system is defined as the network of organs and tissues that help us breathe which includes the airways, lungs, and blood vessels. The muscles that power the lungs are also part of the respiratory system where these parts work together to move oxygen throughout the body and clear out waste gases like carbon dioxide.

Respiratory system works in that way with the immune system by keeping the human from getting sick by bacteria and viruses are removed or swallowed by mucus, while the cilia act like a filter, trapping dust and pollen in the nose.

Thus, coughing involves a quick contraction of the diaphragm muscle, forcing air out while the cilia act like a filter, trapping dust and pollen in the nose. Mucus traps bacteria and viruses to remove or swallow. So, the correct options are A, C and D.

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When a cow is cloned to make exact copies of the adult cow, what is this called?
A) embryonic cloning
B) therapeutic cloning
C) SCNT

Answers

...........The answer is A

Make a list of the energy carriers involved in the Krebs cycle. Include their names before and after they accept the electrons.
Thank you!

Answers

Answer:

12

Explanation:

Please I need this now

Answers

Answer:

D!

Explanation:

Describe the rate of division of cancer cells

Answers

Answer: God bless you

Explanation:

Cancer cells divide without a 'go' signal. Normal cells cease dividing when DNA is damaged, but cancer cells continue. 'Daughter' cells with aberrant DNA or chromosomal numbers result.

What are cancer cells?

Cancer cells are able to divide even if they have not received the signal that says "all clear." Cancer cells, on the other hand, will continue to divide even in the face of genetic (DNA) damage, which causes normal cells to cease dividing. "Daughter" cells are the end product of this process, and they are characterized by aberrant DNA as well as abnormal numbers of chromosomes.

It is possible for cancer cells to detach from the primary tumor and migrate through the circulatory or lymphatic systems to other parts of the body, where they can then form new tumors after emerging from the blood or lymph vessels. This process is known as metastasis. Cancer is a disease that is created when cells divide without control and spread into the tissues that are in close proximity to them.

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3. Two parents bring their 4-year-old son, James, to the doctor because he is having
difficulty walking. He is diagnosed with a genetic disorder called Duchenne muscular
dystrophy, which affects males much more often than females. When genetic testing of
the family is done it is found that James' grandmother, mother, and one of his sisters are
all carriers for the disease. What is the most likely inheritance pattern for this disease?
i

Answers

Answer:

from his mother

Explanation:

because they have one copy of X chromosome from their mother and if X chromosome have DMD gene mutation so he will have DMD

Which of the following is a way that lakes differ from ponds?
A) temperature variation
B) size
C) effect on weather conditions
D) all of the above
PLS HELP ASAP

Answers

the lakes are different than ponds because it effects on weather conditions. pretty sure. i learned this in middle school and it popped into my head that it’s due from weather conditions

Which of the following is the lysosome?

Answers

Answer:

D

Explanation:

1. Show the possible outcomes if a women who is a carrier for baldness has children with a normal man.
Can they have a son with baldness?

Answers

Answer:

Yes they can.

Explanation:

I defined the genotypes and possible outcomes in the image attached

Explain an example why selective breeding is an example of biotechnology

Answers

Example of selective breeding: Cows that produce lots of milk. Selective breeding to create more useful varieties of animals and plants is a form of biotechnology that human beings have used for thousands of years. Biotechnology includes any use of science or technology to alter the characteristics of a particular breed or animal.

Used oll should be
A) O Poured onto grass
B) O Recycled
C) Placed in a container with antifreeze
Shops must follow si
DO Poured down the drain

Answers

Answer:C) Placed in a container with antifreeze

Shops must follow si

Explanation:

hope this helps!!!

love: Deku <3

Answer

C, placed in a container with antifreeze

how is the habitat in arctic tundra

Answers

Answer:

Tundra ecosystems are treeless regions found in the Arctic and on the tops of mountains, where the climate is cold and windy, and rainfall is scant. Tundra lands are covered with snow for much of the year, but summer brings bursts of wildflowers.

What is the significance of the sequence of nitrogen bases in a DNA molecule?

Answers

Answer:

The sequence of the nitrogen bases detremine the order of amino acids in the proteins synthesized.  AKA determine the amino acids in the protein

Explanation:

A DNA is used as a template to create mRNA in a process known as transcription. Transcription occurs in the nucleus and it is catalyzed by an enzyme RNA polymerase.

mRNA moves to the ribosome, and is translated.The nucleotide sequence on the mRNA are arranged in triplets known as codons. The codons on the mRNA are read by the ribosome and used to make a protein.

Thus, the order of nitrogenous bases determines the order of amino acid sequence of the protein synthesized.

The order in which amino acids are added to newly synthesized proteins is determined by the sequence in which nitrogen bases are added.

What are nitrogenous bases?

In the process known as transcription, a DNA molecule serves as a template for the production of mRNA. The nucleus is the location where transcription takes place, and the RNA polymerase enzyme is the catalyst for this process.

The translation process begins when mRNA travels to the ribosome. The nucleotide sequence on the messenger RNA is organized into triplets that are referred to as codons. The ribosome reads the codons that are written on the mRNA and uses that information to make a protein.

Therefore, the sequence of amino acids in the newly synthesized protein is determined by the order in which nitrogenous bases are added.

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1. the process some organisms are able to use by which they convert light energy to chemical energy 2. the main method photosynthesizing organisms use for carbon dioxide fixation Photosynthesis 3. a set of chemical reactions that break down pyruvate, producing electron carriers for an electron transport chain that powers ATP production 4. the process cells use to produce energy from carbohydrates 5. a substance that absorbs some wavelengths of light and reflects others, giving something its color 6. the green substance that absorbs light and provides energy for photosynthesis 7. disc-shaped sacs in chloroplasts in which photosynthesis takes place 8. the series of molecules in the inner membranes of chloroplasts and mitochondria down which excited electrons pass, releasing energy for ATP production 9. process by which NAD is recycled under anaerobic conditions in order to continue the break down of carbohydrates to supply energy for producing ATP 10. adenosine triphosphate, a substance that stores and releases energy for most cell processes 11. describes a process that requires oxygen​

Answers

Considering the given descriptions of metabolic reactions, the correct terms described are:

1.  photosynthesis.

2. photosynthesis

3. citric acid cycle.

4. respiration.

5. pigments.

6. chlorophyll.

7. thylakoids.

8. electron transport chain.

9. fermentation.

10. Adenosine triphosphate

11. Aerobic reactions

What is photosynthesis?

Photosynthesis is one of the many chemical reactions that occur in living organisms.

Photosynthesis is the process by which living organisms known as plants use the energy of sunlight to convert carbon dioxide and water into chemical energy stored in foods.

These chemical reactions are known as metabolic reactions and are essential for the growth and development of the living organism.

Considering the given descriptions of metabolic reactions:

Photosynthesis is the process some organisms are able to use by which they convert light energy to chemical energy. It is the main method by which photosynthesizing organisms use for carbon dioxide fixation to produce food nutrients.

The green pigment that absorbs light and provides energy for photosynthesis is chlorophyll.

Pigments are substances that absorb some wavelengths of light and reflect others, giving something its color.

Chlorophyll is found within chloroplasts. Thylakoids are disc-shaped sacs in chloroplasts where photosynthesis takes place.

Through the process of respiration, cells produce energy from carbohydrates. In living organisms such as man, the citric acid cycle is a set of chemical reactions that break down pyruvate, producing electron carriers for an electron transport chain that powers ATP production.

Adenosine triphosphate, ATP, is a substance that stores and releases energy for most cell processes.

The electron transport chain refers to a series of molecules in the inner membranes of chloroplasts and mitochondria down which excited electrons pass, releasing energy for ATP production.

ATP production can occur under aerobic or anaerobic conditions.

Aerobic reactions are processes that require oxygen​ while anaerobic reactions do not require oxygen.

The process by which NAD is recycled under anaerobic conditions in order to continue the breakdown of carbohydrates to supply energy for producing ATP is called fermentation.

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Which treatment would be considered gene therapy?

removing an organ that is not working properly

giving medicine to match the effects of a gene
working correctly

introducing a new gene to the body

giving medicine to kill infections

Answers

Answer:

introducing a new gene to the body

Explanation:

This because gene therapy is the process where gene from genetic material or DNA is transfered or introduce into the body of a patient to treat diseases or certain infections. This is done to cure ailments. This is a process that modify the gene that is present in the patient body which is the source or cause of the disease and then make it to work normally.

Membrane potential pogil. Pls help

Answers

Uhhhh science right ?

Help As soon as possible !!!

Answers

answers= 1 and 4
adding more coils increases the strength between the poles

9. What happens when most chemical changes take place
a. Only the form of the matter changes.
b. The mass of the matter increases.
c. There is no change in heat.
d. Heat is liberated or absorbed.

Answers

I think it’s the first one - a , but I could be wrong

what is an outcome of lack of oxygen?​

Answers

Answer:

Blood carries oxygen to the cells throughout your body to keep them healthy. Explanation:

Hypoxemia can cause mild problems such as headaches and shortness of breath. In severe cases, it can interfere with heart and brain function. Hypoxemia that causes low oxygen levels in your body's tissues is called hypoxia.

The outcome of lack of oxygen To maintain your body's cells healthy, blood provides oxygen to every cell.

What is cell ?

The smallest unit that can sustain life on its own and makes up all living things, including the body's tissues. The cell membrane, the nucleus, and the cytoplasm are the three primary components of a cell. The substances that enter and leave the cell are governed by the cell membrane, which encloses the cell.

There are two different types of cells: prokaryotic cells, which lack a nucleus but still have a nucleoid area, and eukaryotic cells, which have a nucleus. Eukaryotes can either be single-celled or multicellular, in contrast to prokaryotes, which are single-celled organisms.

From bacteria to humans, cells give all living things their structure and functionality. They are regarded as the tiniest form of life by scientists.

Thus,  To maintain your body's cells healthy, blood provides oxygen to every cell.

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In order to extract DNA from strawberry cells, what will need to happen at the cellular level?

Answers

Answer:

Tiene que romperse la membrana plasmática para poder acceder al núcleo de la célula y posteriormente romperse también la membrana nuclear para dejar libre al ADN

Explanation:

Where does carbon dioxide end up?

Answers

Answer:

Only about 50 percent of the CO2 from human emissions remains in the atmosphere. The remainder is approximately equally split between uptake into the land biosphere and into the ocean.

Explanation:

PLEASE HELP
Which process does this picture show?*

Transcription
Translation
Replication
Transformation

Answers

It would be replication, as you can see the DNA being “ripped” apart by helicase. You can also notice the complementary DNA strands being attached to the original strand.

In the late 1800s, a biologist studying animal embryos coined the phrase "ontogeny recapitulates phylogeny," meaning that the physical development of an animal embryo (ontogeny) seemed to retrace the changing form of the species during its evolutionary history (phylogeny).

Why would embryonic development retrace evolutionary steps?

Answers

Answer:

Embryo provides information about their ancestors.

Explanation:

Embryonic development retrace evolutionary steps because embryo provides evidence for evolution as embryo formation in widely-divergent groups of organisms are conserved. This embryo provides information that leads to their ancestors from which they evolve so we can say that embryonic development provides evidence for evolution of an organism.

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